I would love to find out, just like whoever figured out, that out of the millions of species of plants in the Amazon, that boiling Banisteriopsis caapi and Psychotria viridis together, would make orally active N,N-DMT.
I think there’s a lot more to it than random happenstance. Even in the age of historical written records, civilizations have gone from “advanced” to no one knowing how to read for hundreds of year (like the Bronze Age Collapse).
But again, the idea that a chemist in a lab would not only stumble on the recipe for LSD, but also have the good fortune of ■■■■■■■ spilling it on himself…is pretty damn hard to fathom…so really, I guess similar stuff could be happening every couple of decades…
He didn’t stumble upon it, he accidentally ingested it. I believe it was marked as LSA-25 in the lab, where he observed its euphoric effects on the lab rats before his accidental trip.
The accident happened when he was taking a closer look at that particular variant.
Hofmann became an employee of the pharmaceutical/chemical department of Sandoz Laboratories (now a subsidiary of Novartis), located in Basel as a coworker with professor Arthur Stoll, founder and director of the pharmaceutical department.[7] He began studying the medicinal plantDrimia maritima (squill) and the fungus ergot, as part of a program to purify and synthesize active constituents for use as pharmaceuticals. His main contribution was to elucidate the chemical structure of the common nucleus of the Scillaglycosides (an active principal of Mediterranean squill).[7] While researching lysergic acid derivatives, Hofmann first synthesized LSD on 16 November 1938.[8] The main intention of the synthesis was to obtain a respiratory and circulatory stimulant (analeptic) with no effects on the uterus in analogy to nikethamide (which is also a diethylamide) by introducing this functional group to lysergic acid. It was set aside for five years, until 16 April 1943, when Hofmann decided to reexamine it. While re-synthesizing LSD, he accidentally absorbed a small amount of the drug through his fingertips and discovered its powerful effects.[9] He described what he felt as being:
“Out of the multitude of Bodhisattvas Mahâsattvas who had flocked from other worlds, Bodhisattvas eight (times) equal to the sands of the river Ganges then rose from the assembled circle. Their joined hands stretched out towards the Lord to pay him homage, they said to him: If the Lord will allow us, we also would, after the extinction of the Lord, reveal this Dharmaparyâya in this Saha-world; we would read, write, worship it, and wholly devote ourselves to that law. Therefore, O Lord, deign to grant to us also this Dharmaparyâya. And the Lord answered: Nay, young men of good family, why should you occupy yourselves with this task? I have here in this Saha-world thousands of Bodhisattvas equal to the sands of sixty Ganges rivers, forming the train of one Bodhisattva; and of such Bodhisattvas there is a number equal to the sands of sixty Ganges rivers, each of these Bodhisattvas having an equal number in their train, who at the end of time, at the last period after my extinction, shall keep, read, proclaim this Dharmaparyâya.”