So, around 6 months of taking NADH daily. I still feel great, but I noticed a drop off in the effects. Or perhaps better to say a plateau. So, then I started taking another capsule a day of the “now” brand and it’s worked well. That brand seems to be more powerful. The first time I took it I had so much energy, we cleaned the entire house like a spring cleaning.
So, now I take one “now” and one “Tru” capsule in the morning and again in the afternoon and started getting hairs popping out of my old bald head once again. I don’t mean a mop is growing, but just a hair or two a week on the forehead where I can see. I use my super strong reading glasses to check. My wife laughs at me. Pruning like a 14 year old girl in the mirror.
I going to keep using the “now” brand, but have ordered NMN which is also a NAD+ precursor, but uses a different molecule as a carrier (At least , I think so) that may be more effective according to some.
I don’t think you build up a tolerance to NAD+, so much as I think your body get used to having more in the system and uses it more effectively over time. Once that happens it’s time up the levels again. The article below says you can take up to 2000 mg’s a day. With the extra capsule a day, I’m taking 1000 mgs. If you feel a vit B flushing you probably hit your max level for a while.
" Nicotinamide riboside is likely safe with few — if any — side effects.
In human studies, taking 1,000–2,000 mg per day had no harmful effects (28, 29).
However, most human studies are short in duration and have very few participants. For a more accurate idea of its safety, more robust human studies are needed."