Recreational Marijuana Going Legal in Michigan

SixFoot · December 6, 2019, 1:33pm

Here’s some published reviews from the National Institute of Health on the issue of cannabis as medicine:

Cannabis kills tumor cells
• Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism - PMC
• The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas - PubMed
• In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas - PubMed
• Cannabinoid receptor systems: therapeutic targets for tumour intervention - PubMed
• Predominant CB2 receptor expression in endothelial cells of glioblastoma in humans - PubMed
• Hypothesis: cannabinoid therapy for the treatment of gliomas? - PubMed
• Involvement of cannabinoids in cellular proliferation - PubMed
• Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes - PubMed
• Cannabinoids and gliomas - PubMed
• Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas - PubMed
• The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells - PubMed
• The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway - PubMed
• Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation - PubMed
• Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? - PubMed
• Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines - PubMed
• Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review) - PubMed
• Cannabinoid receptors in human astroglial tumors - PubMed
• Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor - PubMed
Uterine, testicular, and pancreatic cancers
• http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4
• Cannabis-derived substances in cancer therapy--an emerging anti-inflammatory role for the cannabinoids - PubMed

Brain cancer
• Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor - PubMed
Mouth and throat cancer
• Cannabinoids inhibit cellular respiration of human oral cancer cells - PubMed
Breast cancer
• JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells - PubMed
• Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma - PubMed
• The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation - PubMed
Lung cancer
• Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1 - PubMed
• Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1 - PubMed
• Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis - PubMed
Prostate cancer
• Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production - PubMed
• The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications - PMC
• Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms - PubMed
• Cannabinoid receptor as a novel target for the treatment of prostate cancer - PubMed
• Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism - PubMed
• Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: involvement of CB2 - PubMed
Blood cancer
• Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease - PubMed
• Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria - PubMed

Skin cancer
• Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors - PubMed
• The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities - PubMed
Liver cancer
• Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy - PubMed
Cannabis cancer cures (general)
• Inhibition of tumor angiogenesis by cannabinoids - PubMed
• Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas - PubMed
• Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival - PubMed
• Cannabinoids for cancer treatment: progress and promise - PubMed
• Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies? - PubMed
• Cannabinoids and cell fate - PubMed
• Cannabinoids in the treatment of cancer - PubMed
• [The endocannabinoid system as a target for the development of new drugs for cancer therapy] - PubMed
• Cannabinoids and cancer - PubMed
• HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor - PubMed
Cancers of the head and neck
• http://ww.ncbi.nlm.nih.gov/pmc/articles/PMC2277494
Cholangiocarcinoma cancer
• http://ww.ncbi.nlm.nih.gov/pubmed/19916793
• http://www.ncbi.nlm.nih.gov/pubmed/21115947

SixFoot · December 6, 2019, 1:38pm

As far as “non-medicinal” uses go, there’s no such thing.

It’s perfectly OK to get a nice buzz too.

Nemesis · December 6, 2019, 2:43pm

Oh please There are literally millions of Americans who can have a few drinks , maybe take some recreational drugs and it has zero impact on society.

Alcohol is legal but I dont see everyone walking around the office ■■■■■■■■■■ I am not seeing carnage on the roads each morning as drivers are necking backs bottles of whiskey.

Cynic · December 6, 2019, 3:07pm

So back to prohibition…

sikofit · December 6, 2019, 3:29pm

Yes you are free to consider yourself whatever you want. You would be dead wrong in this case as that is hardlyba liberal position but you are still free to think such

PhilipNolan · December 6, 2019, 3:35pm

True alcohol is legal, it’s also very heavily regulated, and the penalties can be quite severe for misuse. Every establishment that sells alcohol, be it a liquor store, grocery store, bar or restaurant needs a special license to serve/sell alcohol. Some states even hold the hosts of private parties liable for alcohol misuse. The manufacture of alcohol is also heavily regulated.

Marijuana has no such regulations. If you want to put it on an equal footing with alcohol & tobacco, then it needs to have the same level of regulation.

Nemesis · December 6, 2019, 3:41pm

PhilipNolan:

Nemesis:

Oh please There are literally millions of Americans who can have a few drinks , maybe take some recreational drugs and it has zero impact on society.
Alcohol is legal but I dont see everyone walking around the office ■■■■■■■■■■ I am not seeing carnage on the roads each morning as drivers are necking backs bottles of whiskey.

True alcohol is legal, it’s also very heavily regulated, and the penalties can be quite severe for misuse. Every establishment that sells alcohol, be it a liquor store, grocery store, bar or restaurant needs a special license to serve/sell alcohol. Some states even hold the hosts of private parties liable for alcohol misuse. The manufacture of alcohol is also heavily regulated.

Marijuana has no such regulations. If you want to put it on an equal footing with alcohol & tobacco, then it needs to have the same level of regulation.

I have no issue with that.

See how easy that was…

sikofit · December 6, 2019, 3:46pm

That is not at true in the slightest. It most certainly does to have regulations in every single state that has legalized

sikofit · December 6, 2019, 3:50pm

Same with cannabis

same with cannabis

PhilipNolan · December 6, 2019, 3:51pm

Do you have that same laissez faire attitude for alcohol, tobacco, “drugs” or even behaviors not deemed appropriate by some?

party-free · December 6, 2019, 4:01pm

I am against the prohibition of alcohol and tobacco, and weed. I have no problem with them being sold legally and regulated and taxed.

How is that laissez faire?

SixFoot · December 6, 2019, 4:04pm

It’s a fair argument. Since fermenting alcohol at home for personal use is legal without a permit or limit to how much you’re allowed to consume each month, so too should growing cannabis at home.

PhilipNolan · December 6, 2019, 4:07pm

be more specific.

PhilipNolan · December 6, 2019, 4:12pm

There’s a disconnect between these two statements, care to connect the dots?

sikofit · December 6, 2019, 4:20pm

Cannabis is regulated in the states its been legalized in, just like alcohol. How can that be any clearer?

SixFoot · December 6, 2019, 4:23pm

For the better part of a century, the government imprisoned you for cannabis.

Now, they want to be your dealer.

sikofit · December 6, 2019, 4:38pm

All the same regulations (and more) you listed for alcohol also exist in the legalized cannabis market satisfying your request.

party-free · December 6, 2019, 4:45pm

There is no disconnect.

party-free · December 6, 2019, 4:45pm

No, they just want to tax the dealer.

Cratic3947 · December 6, 2019, 4:47pm

I hope they do a better job at legalization than California… For some reason our legislature won’t fix the laws. Cal can’t do anything right!

Couldn’t even build a train!