The CDC has estimated that omicron accounts for more than 99% of cases in the U.S. as of Jan. `15. The treatments have been effective against the Delta variant and the original strain.
Treatment with molnupiravir had no effect on the virus titers in the nasal turbinates of the animals infected with the Omicron variant but both compounds dramatically reduced virus titers in the lung to the extent that no virus was recovered from the lungs of all infected hamsters with either molnupiravir or with S-217622. Treatment with S-217622 also resulted in a significant 9.9-fold reduction of virus titers in the nasal turbinates.
Researchers further evaluated the effect of treatment with these compounds in the emergence of resistant variants. Hamsters infected with 103 PFU of the Omicron variant were treated from day 1 post-infection, for 5 days with either molnupiravir or S-217622. No virus was recovered from the lungs of all four animals that were treated with either molnupiravir or S-217622 on Day 7 post-infection. However, low titers of the virus were detected in the nasal turbinates of 3 out of 4 hamsters treated with molnupiravir (2.3, 1.7, and 2.4 log10 PFU/g) and in that of 1 out of 4, S-217622-treated hamsters (3.0 log10 PFU/g).
We do all know that the treatment that is not as effective are one’s like Regeneron… right?
That there are other Monoclonal treatments that are in short supply because it takes time to produce them and giving them away willy nilly is a terrible way to distribute the scarce resource… right?
It is like sooooo much hay is made about the waning effectiveness of the vaccines and about how we were all lied to about all of that… but the monoclonal treatments that were effective last year just can’t lose effectiveness… and to withhold them is KILLING PEOPLE!!!
I think that the vaccines effectiveness against the variant they were designed for does wane over time. Hence the booster.
However monoclonal treatments I believe are just as effective today against the variant they were designed as last year. The difference is the virus has changed.
Yes any mAB treatment will have “-mab” in its name.
“-Vir” indicates antiviral.
Molnupiravir is the Merck antiviral.
Gotta be careful with it though as it may cause tumors.
The Pfizer antiviral is also not to be taken with a lot of common drugs such as statins that people most at risk for serious COVID are likely to be taking.