Chloroquine and Hydroxychloroquine Coronavirus cures?

[WuWei]

@SottoVoce

By the sixth day of treatment, 11 patients had died, leading to an immediate end to the high-dose segment of the trial.

From the drug?

[SottoVoce]

@WuWei

@SottoVoce

By the sixth day of treatment, 11 patients had died, leading to an immediate end to the high-dose segment of the trial.

From the drug?

Yes. They developed fatal heart arrhythmias. Hydroxychloroquine and chloroquine both prolong the QT interval. If severe, you die.

https://www.dicardiology.com/article/covid-19-hydroxychloroquine-treatment-brings-prolonged-qt-arrhythmia-issues

[Samm]

@SottoVoce

By the sixth day of treatment, 11 patients had died, leading to an immediate end to the high-dose segment of the trial.

I expect that being unable to breathe may have had a lot to do with that.

[Bosun]

That is what I was trying to determine, too. was it compassionate use where there were too many complications? Sneakydude I suspect that there a lot of “experts” who do not have a clue and use fake news talking points.

[STODR]

@WildRose

The states failed to prepare in spite of decades of warnings and time to do it.

With the states failig to do so, they overwhelmed the Federal Pandemic Response capability.

This is a state/local failure because it is their duty to be prepared and it is then only the responsibility of the Federal Gov’t to come in and help when the state/locals have been overwhelmed just like any other disaster.

Why do you think we have state gov’ts to begin with? Why do you blame the Fed’s for the failures of the state/local gov’ts?

Can you imagine what the Libs would have said and done if Trump would have shut down the Dems nomination process and sent the Senate home during the impeachment due to some flu in China? ■■■■■■ Shifty and Nasty Nancy would have immediately started another impeachment.

[Bosun]

They are going to try that anyway. Adam Pile of Schiff has already indicated he is ready. No Blink Nancy is a basket case.

[SottoVoce]

@Samm

@SottoVoce

By the sixth day of treatment, 11 patients had died, leading to an immediate end to the high-dose segment of the trial.

I expect that being unable to breathe may have had a lot to do with that.

Here’s more from the article.

Within three days, researchers started noticing heart arrhythmias in patients taking the higher dose. By the sixth day of treatment, 11 patients had died, leading to an immediate end to the high-dose segment of the trial.

Here is an quote from the actual study.

The high dose CQ arm presented more QTc>500ms (25%), and a trend toward higher lethality (17%) than the lower dosage.

2020.04.07.20056424v1.full.pdf

[Bosun]

Who authorized the higher dose?

[WuWei]

These 11?

[SottoVoce]

In the high-dose segment, all of those that died did so because of a fatal arrhythmia. Over a quarter of those in the high-dose segment developed an arrhythmia. In the low-dose segment, 10% developed an arrhythmia but none died from it.

[SottoVoce]

@Bosun

Who authorized the higher dose?

Brazilian Committee of Ethics in Human Research (CONEP approval 3.929.646/2020)

[Bosun]

Sounds like they screwed up.who is CONEP? Same folks? You better check with W.H.O. for the “best” information on how to screw something up.

[Samm]

@Bosun

Sounds like they screwed up.

Not really. The are in virgin territory, there is no map.

[Bosun]

Are you telling me this is Amateur Hour, Samm?

[PeterGriffin]

How is this virgin territory? This drug has been around for 50 years. These are well known side effects.

[PeterGriffin]

Amateur pharmacologists buying into Magic Pill Happy Talk.

[Paul_Thomson]

Breaking the Malthusian code offends a few here.

[Samm]

I wouldn’t say amateur … these people doing these trials are highly trained and skilled. They just have no information to go on other then knowing what the drugs are designed to do and what side effects are known to exist. Its really no different than any other professional using a known product for something that it was not designed for because in the realm of their knowledge and experience, there is a reasonable expectation that it might work.

[SottoVoce]

@Bosun

Sounds like they screwed up.who is CONEP? Same folks? You better check with W.H.O. for the “best” information on how to screw something up.

Perhaps you could write or visit Brazil and encourage them to change their research process to fit your standards.

R&D Opportunities and Challenges in Brazil

The regulatory process to approve clinical trials in the country requires approval by two entities, an ethical approval by CONEP (Comissão Nacional de Éticaem Pesquisa/National Ethics Commission) and a regulatory approval by ANVISA (Agência Nacional de Vigilância Sanitária/National Agency of Health Surveillance).

[Samm]

@PeterGriffin

How is this virgin territory? This drug has been around for 50 years. These are well known side effects.

It has never been used to treat the symptoms of Novel Coronavirus infection. That makes it virgin territory. I find it odd that you would even have to ask.